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Publications

McCarthy Cameron G, Aalkjær Christian, Bagher Pooneh, Beyer Andreas M, Boedtkjer Ebbe, Bomfim Gisele F, Breslin Jerome W, Briones Ana M, Castorena-Gonzalez Jorge A, Costa Tiago J, Dai Zhiyu, Davel Ana P, Earley Scott, Freed Julie K, Garland Christopher, Isakson Brant E, Jepps Thomas A, Kalucka Joanna, Lavanderos Boris, Makino Ayako, Norton Charles E, Segal Steven S, Tan Wenbin, Trask Aaron J, , Zawieja Scott D, Wenceslau Camilla F

American Journal of Physiology - Heart and Circulatory Physiology (2026)

, Clark R A, Buckley C, , Uhlen P, ,

Acta Physiologica Vol 241 (2025)

, Osborne Christopher, , MacDonald Amy, Ebner Grace, Jeffrey Danielle A, Macdonald Margaret A, , Buckley Charlotte, Dabertrand Fabrice, Machin Daniel R, Au Jason, Harraz Osama F, Tykocki Nathan, ,

The Journal of Physiology Vol 603, pp. 6763-6781 (2025)

Tavoulari Sotiria,

IUPHAR/BPS Guide to Pharmacology CITE Vol 2025 (2025)

, , , , Buckley Charlotte, , ,

(2025)

Buckley C, , , ,

FASEB Journal Vol 39 (2025)

Teaching

Final-year Biomolecular Sciences Research Projects – I manage and coordinate final-year research projects in the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS). This role involves the coordination of over 40 members of academic staff and 200+ students. I deliver a number of workshops on topics such as critical review, written and oral presentation, effective communication and report structuring.

Cardiovascular Pharmacology - I lecture on Cardiovascular Pharmacology throughout the Biomolecular Sciences degree programmes in SIPBS.

Research Interests

Research Overview:

All blood vessels in the body are lined by a single layer of cells called the endothelium. The cells that make up this layer (endothelial cells) have many important functions, such as controlling blood flow and blood clotting. These cells are the front line in cardiovascular health, and are involved in most human diseases. For example, endothelial cells allow cancer tumours to grow, and they malfunction in Alzheimer’ disease. The driving focus of my research is to define how endothelial cells work, and so identify new targets for disease treatment and prevention. Broadly, my research contributions cover the following:

1. Vascular discovery science infrastructure

I have developed an extensive portfolio of methodologies, hardware, and software to probe blood vessel function. These include novel microscopes for blood vessel imaging, open-source pressure myography, advanced calcium imaging techniques, and signal processing software.

These tools provide new ways to explore blood vessel behaviour and will accelerate the convergence of vascular discovery science and medicine.

2. Vascular discovery science

Using the above techniques, I provide new insights into blood vessel behaviour. For example, I established that the neurotransmitter, acetylcholine, is a physiological regulator of blood flow. I demonstrated that mitochondria are required for endothelial function. By applying my tools to animal models of disease, my work is beginning to reveal the molecular and physiological mechanisms that give rise to vascular dysfunction.

These discoveries inform novel therapeutic strategies to treat blood vessel dysfunction in cardiovascular disease.

3. Open-source physiology

I am driven by a desire to improve research through Open Science - the free sharing of publications, datasets, and software/hardware. To promote Open Science in physiology, I developed the VasoTracker platform (www.vasotracker.com) to freely distribute open-source tools arising from my research. I also contribute to the IUPHAR/BPS Guide to Pharmacology (bit.ly/3qax6xG )

Open-source physiology will increase the accessibility, usability and reproducibility of vascular research.

Professional Activities

Examiner

16/4/2024

Organiser

2024

Speaker

2024

Advisor

2023

Peer reviewer

2023

Chair

2023

Projects

McCarron, John (Principal Investigator) Buckley, Charlotte (Co-investigator) Wilson, Calum (Co-investigator)

19-Jan-2021 - 18-Jan-2026

McCarron, John (Principal Investigator) Buckley, Charlotte (Co-investigator) Chalmers, Susan (Co-investigator) Wilson, Calum (Co-investigator)

Mitochondrial control of voltage-dependent calcium entry in hypertension

03-Jan-2020 - 08-Jan-2024

Wilson, Calum (Fellow)

17-Jan-2017 - 16-Jan-2021

McCarron, John (Principal Investigator) Wilson, Calum (Co-investigator)

01-Jan-2017 - 03-Jan-2021

McCarron, John (Principal Investigator) Wilson, Calum (Co-investigator)

Endothelial acetylcholine release accounts for flow-mediated dilation and is impaired in type 2 diabetes

09-Jan-2017 - 25-Jan-2020

Wilson, Calum (Research Co-investigator)

01-Jan-2010 - 22-Jan-2015