Dr Martin Wiese
John Anderson Research Senior Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences
Personal statement
I joined the University in 2007 and I鈥檓 currently a John Anderson Research Senior Lecturer in Molecular Parasitology and Biochemistry. I mainly teach Biochemistry to undergraduate and postgraduate students. I am involving students in current research projects to provide them with state-of-the-art methods and technologies. This allows them to make an informed decision on their future careers and provides them with appropriate background knowledge to aid them in their personal development. In my research I am investigating Leishmania protein kinases as potential drug targets to cure leishmaniasis and as crucial regulators in flagellum formation and maintenance.
As the Leader of the Infection, Immunity and Microbiology Research Group from 2011-2014 I was involved in the general organisation of SIPBS.
The following topics are currently available in my group to do a PhD (subject to funding):
鈥淪ignalling pathways in Leishmania 鈥� drug targets to treat human leishmaniasis鈥�
鈥淯sing genetic analysis to decipher flagellum formation and maintenance in Leishmania鈥�
鈥淢olecular genetic analysis of Leishmania to identify protein kinase drug targets鈥�
鈥淜inesins and kinases 鈥� protein interaction and phenotypic analysis of genetically modified Leishmania 辫补谤补蝉颈迟别蝉鈥�
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Publications
- Topuz Ata Derya, , Jones Michael, Best Jonathan, , Carter Katharine Christine
- Microorganisms Vol 11 (2023)
- Al Kufi Suad Gazi Jaafer, Emmerson Josiah, Rosenqvist Heidi, Garcia Catarina Mateus Moreira, Rios-Szwed Diana Onodelia,
- Scientific Reports Vol 12 (2022)
- Hall Amy R, Blakeman Jamie T, Eissa Ahmed M, Chapman Paul, Morales-Garc铆a Ana L, Stennett Laura, Martin Oihane, Giraud Emilie, Dockrell David H, Cameron Neil R, , Yakop Laith, Rogers Matthew E, Geoghegan Mark
- Chemical Science Vol 11, pp. 10973-10983 (2020)
- Hombach-Barrigah Antje, Bartsch Katharina, Smirlis Despina, Rosenqvist Heidi, MacDonald Andrea, Dingli Florent, Loew Damarys, Sp盲th Gerald F, Rachidi Najma, , Clos Joachim
- Scientific Reports Vol 9 (2019)
- Goldman-Pinkovich Adele, Balno Caitlin, Strasser Rona, Zeituni-Molad Michal, Bendelak Keren, Rentsch Doris, Ephros Moshe, , Jardim Armando, Myler Peter J, Zilberstein Dan
- PLOS Pathogens Vol 12 (2016)
- Cayla Mathieu, Rachidi Najma, Leclercq Olivier, Schmidt-Arras Dirk, Rosenqvist Heidi, , Sp盲th Gerald F
- PLOS Pathogens Vol 10 (2014)
Research Interests
My research focuses on Leishmania protein kinases as potential drug targets and as important regulators for flagellum maintenance. Leishmania is a protozoan parasite that can cause death in infected humans and animals. Protein kinases have been shown to be essential for survival of this parasite in the infected host. Hence, specific inhibitors for parasite protein kinases have the potential to be ideal drugs to treat leishmaniasis. On the other hand Leishmania has a single flagellum containing structures conserved in all organisms forming cilia or flagella including humans. Understanding how flagellum formation and maintenance is regulated in Leishmania will help to understand and cure human disorders affecting the function of cilia and flagella. I am using phosphoproteomics, molecular parasitology and protein biochemistry to identify relevant protein kinases, their activators and substrates. This will allow me to develop enzyme assays to screen for inhibitors of the target protein kinases, which can be developed into useful medicines.
Professional Activities
- Invited speaker
- 22/3/2015
- Speaker
- 4/2009
Projects
- Wiese, Martin (Principal Investigator)
- 01-Jan-2007 - 30-Jan-2011
Contact
Dr
Martin
Wiese
John Anderson Research Senior Lecturer
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: martin.wiese@strath.ac.uk
Tel: 548 2678