Dr Zahra Rattray
Professor
Strathclyde Institute of Pharmacy and Biomedical Sciences
Personal statement
Professor of Translational Pharmaceutics I am a pharmacist by training with experience of working within the hospital, community and industry sectors. I have contributed to a diverse molecule portfolio spanning pre-clinical to late-stage development during my time at AstraZeneca and in collaboration with Patrys Ltd at the Yale School of Medicine (PAT-DX1). My research team has two overall interests; i) Analytical characterization of new modality parenteral formulation attributes and in vivo performance: A key challenge in the commercial translation of newly-discovered drugs is understanding the key performance indicating characteristics crucial to their biological performance and how they interact with living systems. We are interested in developing new tools to profile these performance characteristics. Areas of research interest in my lab are summarized as follows; Understanding the environmental and physicochemical determinants of solution-phase formulation stability for antibody and suspension formulations. Determining key critical quality attributes in particle design to inform optimal in vivo performance. Analytical evaluation of nanomedicine interaction with biological media, and the mechanism of cellular uptake in two- and three-dimensional cellular models. Applying novel imaging modalities for evaluating drug and nanoparticle biodistribution, and impact on tumor response. The interplay between the tumour microenvironment and nanomedicine in vivo performance with a view to developing biorelevant in vitro tests. ii) DNA repair agents, the nuclear import pathway, and their role in cancer: We are interested in screening the functional and phenotypic role of DNA repair mutations. We also develop new small molecule drugs against various nuclear import transporters known to be elevated in cancer.
Prize And Awards
- Recipient
- 11/2024
- Recipient
- 8/2024
- Recipient
- 8/2024
- Recipient
- 2024
- Recipient
- 2024
- Recipient
- 2024
Publications
- Cai Yuping, , Zhang Qian, Mironova Varvara, Santos-Neto Alvaro, Hsu Kuo-Shun, , Cross Justin R, Zhang Yawei, Paty Philip B, Khan Sajid A, Johnson Caroline H
- Scientific Reports Vol 10 (2020)
- , Deng Gang, Zhang Shenqi, Shirali Anupama, May Christopher K, Chen Xiaoyong, Cuffari Benedette J, Liu Jun, Zou Pan, , Johnson Caroline H, Dubljevic Valentina, Campbell James A, Huttner Anita, Baehring Joachim M, Zhou Jiangbing, Hansen James E
- JCI Insight Vol 6 (2021)
- , Trivedi Drupad K, Xu Yun, Chandola Tarani, Johnson Caroline H, Marshall Alan D, Mekli Krisztina, , Tampubolon Gindo, Vanhoutte Bram, White Iain R, Wu Frederick CW, Pendleton Neil, Nazroo James, Goodacre Royston
- Nature Communications Vol 10 (2019)
- , Zindy Egor, Buzza Karen M, Pluen Alain
- Protein Self-Assembly Methods and Protocols (2019) (2019)
- , Dubljevic Valentina, , Greenwood Deanne L, Johnson Caroline H, Campbell James A, Hansen James E
- Biochemical and Biophysical Research Communications Vol 496, pp. 858-864 (2018)
- , Patel Jaymin M, Noble Phillip W, Dubljevic Valentina, Greenwood Deanne L, Campbell James A, Hansen James E
- Cancer Research Vol 78, pp. 2773 (2018)
Professional Activities
- Member
- 6/7/2021
- Chair
- 4/2021
- Host
- 4/2026
- Speaker
- 25/2/2026
- Examiner
- 6/2/2026
- Examiner
- 27/1/2026
Projects
- Perrie, Yvonne (Principal Investigator) Rattray, Zahra (Co-investigator) Sanchez Garcia, Eugenia (Research Co-investigator)
- 01-Jan-2025 - 01-Jan-2029
- Rattray, Zahra (Principal Investigator) Burley, Glenn (Co-investigator) Willis, Liam (Research Co-investigator)
- 01-Jan-2025 - 01-Jan-2029
- Rattray, Zahra (Principal Investigator) Perrie, Yvonne (Co-investigator) Gray, Olivia (Research Co-investigator)
- 01-Jan-2025 - 01-Jan-2029
- Perrie, Yvonne (Principal Investigator) Rattray, Zahra (Co-investigator) Falcao David, Ana Beatriz (Research Co-investigator)
- 01-Jan-2025 - 01-Jan-2029
- Rattray, Zahra (Principal Investigator) Perrie, Yvonne (Co-investigator)
- 01-Jan-2025 - 31-Jan-2029
- Burley, Glenn (Co-investigator) Rattray, Zahra (Co-investigator)
- 01-Jan-2025 - 30-Jan-2030
Contact
Dr
Zahra
Rattray
Professor
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: zahra.rattray@strath.ac.uk
Tel: 548 2106