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Publications

Bole Leonie J, Uzelac Marina, Hern谩n-G贸mez Alberto, , O'Hara Charles T, Hevia Eva

Inorganic Chemistry Vol 60, pp. 13784-13796 (2021)

Touchet Sabrina, Yeardley Callum, O'Hara Charles T, Gros Philippe C

European Journal of Organic Chemistry Vol 2021, pp. 4835-4845 (2021)

Gauld Richard M, McLellan Ross, , Carson Freya J, Barker Jim, Reid Jacqueline, O'Hara Charles T,

European Journal of Inorganic Chemistry Vol 2021, pp. 1615-1622 (2021)

Bru帽a Sonia, , Fairley Michael, O'Hara Charles T

Chemistry - A European Journal Vol 27, pp. 4134-4140 (2021)

Fairley Michael, Bole Leonie J, Mulks Florian F, Main Laura, , O'Hara Charles T, Garc铆a-脕lvarez Joaquin, Eva Hevia

Chemical Science Vol 11, pp. 6500-6509 (2020)

Yeardley Callum, , Gros Philippe C, Touchet Sabrina, Fairley Michael, McLellan Ross, Mart铆nez-Mart铆nez Antonio J, O'Hara Charles T

Dalton Transactions Vol 49, pp. 5257-5263 (2020)

Professional Activities

Organiser

11/9/2015

Participant

29/6/2015

Organiser

1/4/2015

Contributor

4/3/2015

Member

4/2014

Contributor

1/4/2014

Projects

Nelson, David (Principal Investigator) O'Hara, Charles (Co-investigator) Oultram, Samuel (Research Co-investigator)

01-Jan-2024 - 01-Jan-2028

Nelson, David (Principal Investigator) O'Hara, Charles (Co-investigator) Oultram, Samuel (Research Co-investigator)

01-Jan-2024 - 01-Jan-2028

O'Hara, Charles (Principal Investigator)

New Bimetallic Chiral Reagents for Asymmetric Synthesis

01-Jan-2018 - 28-Jan-2020

O'Hara, Charles (Principal Investigator)

01-Jan-2017 - 29-Jan-2021

Hevia, Eva (Principal Investigator) O'Hara, Charles (Co-investigator) Fairley, Michael (Research Co-investigator)

01-Jan-2015 - 17-Jan-2020

O'Hara, Charles (Principal Investigator)

"Copper metal has been used by humans for at least the past 10,000 years. Native copper was one of the first metals discovered as it can exist in an uncombined form, and not as a natural mineral like most other more reactive metals. In the 20th century, copper emerged as an important metal for electrical wiring, pipework, architecture and industrial machinery, mainly due to its favourable chemical and physical properties including its ductility, very high electrical and thermal conductivity, durability and corrosion resistance. Copper also has an important biological role. It is an essential trace element, which is vital for the proper functioning of the body's organs and metabolism.

Copper is generally considered as a very unreactive metal; however, when it is chemically-combined with an organic (carbon-containing) molecule to produce an organocopper compound, a vastly different situation arises. One of the first organocopper reagents synthesised, methylcopper, is in fact highly explosive and too reactive to produce a safe, manageable and reproducible chemistry. But when combined with an organolithium compound, the new mixed lithium copper reagent displays a much higher stability which can be harvested to produce an exciting, useful chemistry allowing for a multitude of catalytic chemical transformations to be developed. This has allowed the facile synthesis of new important molecules, which over the past few years have transformed the pharmaceutical industry. Up until now, the fundamental science at play has dictated than these lithium copper reagents exist as lithium cuprates meaning that the lithium centre is formally positively charged, whilst the copper centre holds the negatively charged organic groups rendering it formally negatively charged.

In our group, we have recently made the breakthrough that it is possible to prepare a brand new type of lithium copper compound, where the positive-negative role that each metal plays has been reversed, producing an unprecedented copper lithiate. In this project, the scope of formation and catalytic reactivity of compounds displaying this new formulation and polarity reversal will be fully explored. Results from this new direction within mixed lithium copper chemistry will undoubtedly appeal to a broad spectrum of academics, including inorganic, organometallic and organic chemists, as well as to supramolecular chemists due to the unprecedented structural and coordination chemistry. This new methodology extended to catalysis will also be of considerable interest to researchers in the chemical industry (fine chemicals, pharmaceutical, agrochemical etc.) who strive to produce new key molecules in a facile manner for the benefit of humankind."

01-Jan-2013 - 30-Jan-2015