ÌÇÐÄÊÓƵ

Publications

, Loudin James, Goetz Georges, Huie Philip, Wang Lele, Kamins Theodore I, Galambos Ludwig, Smith Richard, Harris James S, Sher Alexander, Palanker Daniel

Nature Photonics Vol 6, pp. 391-397 (2012)

Scharf Robert, Tsunematsu Tomomi, , , ,

Scientific Reports Vol 6 (2016)

Lorach Henri, Goetz Georges, Smith Richard, Lei Xin, Mandel Yossi, Kamins Theodore, , Huie Philip, Harris James, Sher Alexander, Palanker Daniel

Nature Medicine Vol 21, pp. 476–482 (2015)

, Verdier Antonin, , , Callas Ella, , Aniorte Alicia, Mabrouk Kakaouia Eya, Pereyra Magdalena, , Bathellier Brice,

Nature Communications Vol 17 (2026)

Shin Andrew, Jensen Nathan, , An Jeonghyun, Pham-Howard Davis, Galambos Ludwig, , Kamins Theodore, Palanker Daniel

Journal of Neural Engineering Vol 22 (2025)

Byron Nicole, , Pisano Filippo, Pisanello Marco, Ferreira Jacques, Montinaro Cinzia, , De Vittorio Massimo, Pisanello Ferruccio,

Neurophotonics Vol 12 (2025)

Research Interests

Professional Activities

Recipient

20/5/2026

Examiner

27/4/2026

Examiner

15/4/2026

Participant

23/3/2026

Speaker

25/11/2025

Examiner

7/11/2025

Projects

Mathieson, Keith (Principal Investigator)

11-Jan-2025 - 10-Jan-2026

Mathieson, Keith (Principal Investigator)

01-Jan-2025 - 31-Jan-2026

Mathieson, Keith (Principal Investigator) Sakata, Shuzo (Co-investigator) Vladimirova, Vanesa (Research Co-investigator)

01-Jan-2024 - 01-Jan-2028

Mathieson, Keith (Principal Investigator) Sakata, Shuzo (Co-investigator) Vladimirova, Vanesa (Research Co-investigator)

01-Jan-2024 - 01-Jan-2028

McAlinden, Niall (Principal Investigator) Mathieson, Keith (Academic) Stoyanov, Svetoslav (Researcher)

There is a growing demand for wireless, site-specific optogenetic devices that enable precise neural modulation without constraining naturalistic animal behaviour. Tapered optical fibres are commonly used in optogenetics because they enable multisite and large-volume illumination within a minimally invasive probe, while also serving as both excitation and collection elements for fibre photometry. Their tapered geometry acts as a mode demultiplexer: higher-order modes emit near the base of the taper, whereas lower-order modes emit closer to the tip. However, achieving controlled mode-selective coupling into multimode fibres typically requires bulky optical hardware, meaning that in vivo experiments rely on tethered fibre-optic connections. These tethers restrict natural movement and limit the range of behavioural paradigms that can be explored.

To overcome these constraints, we have developed a lightweight (<3 g, including battery) wireless headstage capable of driving tapered‑fibre optogenetics. The system integrates a wireless communication module with a multi‑site light‑delivery module. The communication module consists of an STM microcontroller with integrated Bluetooth and an Intan digital electrophysiology stimulator/amplifier microchip which in this device supports electrical recording from four channels at up to 20 kHz sampling rate and provides sufficient current to drive four light sources. The light delivery module includes 4 edge-emitting semiconductor lasers which are mounted so that they couple into a fibre optic at different angles. This configuration enables independent illumination of four distinct sites along the tapered fibre.

01-Jan-2024

Mathieson, Keith (Principal Investigator) McAlinden, Niall (Research Co-investigator)

01-Jan-2023 - 31-Jan-2025