糖心视频

Publications

Camus St茅phane M, Camus Marine D, Figueras-Novoa Carmen, Boncompain Gaelle, Sadacca L Amanda, Esk Christopher, Bigot Anne, , Kioumourtzoglou Dimitrios, Perez Franck, Bryant Nia J, Mukherjee Shaeri, Brodsky Frances M

Journal of Cell Biology Vol 219 (2019)

Bowman Peter R T, Smith Godfrey L,

PLoS One Vol 14 (2019)

Sadler Jessica B A, Lamb Christopher A, Welburn Cassie R, Adamson Iain S, Kioumourtzoglou Dimitrios, Chi Nai-Wen, , Bryant Nia J

Scientific Reports Vol 9 (2019)

Seminars in Cell and Developmental Biology Vol 53, pp. 64-73 (2016)

Sadler Jessica BA, Bryant Nia J,

Molecular Biology of the Cell Vol 26, pp. 530-536 (2015)

Kioumourtzoglou Dimitrios, , Bryant Nia J

Molecular and Cellular Biology Vol 34, pp. 1271-1279 (2014)

Research Interests

A major consequence of insulin action is a dramatic increase in the rate of glucose transport into fat and muscle. This is achieved by the delivery of the facilitative glucose transporter GLUT4 from insulin-sensitive intracellular stores to the cell surface. Insulin-stimulated glucose transport is impaired in Type-2 diabetes; this is underpinned by reduced delivery of GLUT4 to the cell surface. Metabolic disorders such as Type-2 diabetes are linked to the development of cardiovascular disease. Our lab uses cellular, genetic and systems biology approaches to understand insulin regulated GLUT4 trafficking in different cells.

Studies in our group use a range of experimental systems and approaches. These include genome editing of cultured adipocytes to probe the regulatory pathways controlling GLUT4 trafficking and activity, cutting-edge imaging techniques including STED-FCS and dSTORM, analysis of signalling and trafficking in subcellular fractions and analysis of transport kinetics in intact cells. We also employ Saccharomyces cerevisiae听as a tool to study membrane trafficking.

Professional Activities

Editorial board member

2019

Editorial board member

2017

Editorial board member

2017

Invited speaker

22/8/2025

Organiser

22/8/2025

Contributor

2/7/2025

Projects

Cunningham, Margaret Rose (Principal Investigator) Wahid, Maheen (CoPI) Tinto, Kirsty (CoPI) Murray, James (Co-investigator) Currie, Susan (Co-investigator) Boyd, Marie (Co-investigator) Perrie, Yvonne (Co-investigator) Gould, Gwyn (Co-investigator)

AWERB 3Rs Prize 2024 - Strathclyde 3R's: Reduction, Refinement and Replacement Prize

01-Jan-2025

Gould, Gwyn (Principal Investigator) Faulds, Karen (Co-investigator) Tomkinson, Nick (Co-investigator)

01-Jan-2024 - 30-Jan-2027

Gould, Gwyn (Principal Investigator) Li, David (Co-investigator) McConnell, Gail (Co-investigator) Van de Linde, Sebastian (Co-investigator)

15-Jan-2023 - 14-Jan-2026

Gould, Gwyn (Principal Investigator)

10-Jan-2023 - 04-Jan-2026

McGeown, William (Principal Investigator) Mavroeidi, Alexandra (Principal Investigator) Parra Rodriguez, Mario (Co-investigator) Brown Nicholls, Louise (Co-investigator) Rasmussen, Susan (Co-investigator) Robertson, David (Co-investigator) Tse, Dwight (Co-investigator) Kirk, Alison (Co-investigator) Hafford-Letchfield, Trish (Co-investigator) Rattray, Nicholas (Co-investigator) Bushell, Trevor (Co-investigator) Gould, Gwyn (Co-investigator) GANGANNAGARIPALLI, Jaheedabegum (Co-investigator) Carswell, Hilary (Co-investigator) Tate, Rothwelle (Co-investigator) Kurdi, Amanj (Co-investigator) Lennon, Marilyn (Co-investigator) Moshfeghi, Yashar (Co-investigator) Roper, Marc (Co-investigator) McConnell, Gail (Co-investigator) Kerr, Andy (Co-investigator) Li, David (Co-investigator) Thomson, Avril (Co-investigator) Campbell, Gerard (Co-investigator) Vourganas, Ioannis (Co-investigator) Clark, Ruaridh (Co-investigator) Macdonald, Malcolm (Co-investigator)

HaSS Bridging Disciplines.

Successfully funded for access to UK Biobank:

The overarching aim of the application is to investigate the predictors (e.g., lifestyle, neuroimaging metabolic and genetic) of healthy ageing (e.g., cognitive, physical and mental health in older age).

Our objectives are to identify the contribution of predictors (lifestyle, medication-related, neuroimaging, metabolic, and genetic) of the following outcomes, that occur at greater frequency in older age:
1) Cognitive impairment (e.g., due to normal ageing or neurological disorders such as Alzheimer鈥檚 disease, stroke)
2) Poor physical health (e.g., osteoporosis, diabetes, falls and fractures)
3) Poor mental health (e.g., anxiety, depression, suicidal ideation)

08-Jan-2023 - 09-Jan-2025

McConnell, Gail (Principal Investigator) Gould, Gwyn (Co-investigator) Brown, Mollie (Research Co-investigator)

01-Jan-2022 - 01-Jan-2026