Dr Trevor Bushell
Reader
Strathclyde Institute of Pharmacy and Biomedical Sciences
Personal statement
I obtained my BSc (Hons) in Pharmacology from the University of Glasgow (1992) and my PhD in Neuroscience from the University of Bristol (1996) before undertaking postdoctoral research at the University of Chicago and Imperial College London. I took up my position here at Strathclyde in 2002.
My research interest lies primarily in the field of neuroscience and focuses on the modulation of neuronal excitability and synaptic transmission in both physiological and pathophysiological conditions. This currently takes several directions including the following:聽
- Identifying novel roles for protease-activated receptor 2 (PAR-2) in the central nervous system (CNS).
- Examining how peripheral inflammation affect CNS function and animal behaviour (with Dr Hui-Rong Jiang)
- Determining the role of Toll-like receptor 3 (TLR3) in the CNS development.聽
- Investigating the role of mitogen-activated protein kinase phosphatase-2 (MKP2) in the CNS.
- Developing novel microfluidic devices for neuroscience research (with Dr Michele Zagnoni).
A variety of preparations are utilised in our research including mammalian expression systems, cultured neurones, organotypic slice cultures and acute brain slices. Techniques used include cell death assays, electrophysiology, immunocytochemistry, overexpression of fluorescently tagged proteins of interest, molecular biological techniques including site-directed mutagenesis and real time RT-PCR and in collaboration with聽聽Professor Judy Pratt we utilise a variety of tests to understand rodent behaviour.聽
I am involved in teaching both the MPharm and BMS cohorts in numerous classes ranging from 1st to 4th year.聽 In addition I am lead of the Neuroscience and Mental Health research group.
I am currently the Strathclyde local group representative for the聽.聽 I am also a full member of the Society for Neuroscience and a Fellow of the Higher Education Academy.
Prize And Awards
- Recipient
- 24/2/2025
Publications
- Moudio Serge, Nuthall Hugh N,
- Brain and Neuroscience Advances Vol 9 (2025)
- , Schniete Jana Katharina, , Dempster John, Hansen Carsten Gram, Shaw Michael, ,
- Journal of Microscopy Vol 295, pp. 33-41 (2023)
- Tinning Peter W, Schniete Jana K, Scrimgeour Ross, , , ,
- Optics Letters Vol 48, pp. 1092-1095 (2023)
- , Megarity Daniel,
- BioMedEng22 (2022)
- Megarity D, , Kriek M, Downey P, ,
- Lab on a Chip Vol 22, pp. 1989-2000 (2022)
- Barbour Mark, Wood Rachel, Harte Tanith, ,
- Immunology Vol 165, pp. 312-327 (2022)
Professional Activities
- Examiner
- 3/12/2025
- Examiner
- 2025
- Participant
- 2025
- Advisor
- 2025
- Contributor
- 6/7/2023
- Contributor
- 6/7/2023
Projects
- Bushell, Trevor (Principal Investigator)
- 01-Jan-2024 - 31-Jan-2024
- Bushell, Trevor (Principal Investigator)
- 01-Jan-2024 - 31-Jan-2024
- McGeown, William (Principal Investigator) Mavroeidi, Alexandra (Principal Investigator) Parra Rodriguez, Mario (Co-investigator) Brown Nicholls, Louise (Co-investigator) Rasmussen, Susan (Co-investigator) Robertson, David (Co-investigator) Tse, Dwight (Co-investigator) Kirk, Alison (Co-investigator) Hafford-Letchfield, Trish (Co-investigator) Rattray, Nicholas (Co-investigator) Bushell, Trevor (Co-investigator) Gould, Gwyn (Co-investigator) GANGANNAGARIPALLI, Jaheedabegum (Co-investigator) Carswell, Hilary (Co-investigator) Tate, Rothwelle (Co-investigator) Kurdi, Amanj (Co-investigator) Lennon, Marilyn (Co-investigator) Moshfeghi, Yashar (Co-investigator) Roper, Marc (Co-investigator) McConnell, Gail (Co-investigator) Kerr, Andy (Co-investigator) Li, David (Co-investigator) Thomson, Avril (Co-investigator) Campbell, Gerard (Co-investigator) Vourganas, Ioannis (Co-investigator) Clark, Ruaridh (Co-investigator) Macdonald, Malcolm (Co-investigator)
- HaSS Bridging Disciplines.
Successfully funded for access to UK Biobank:
The overarching aim of the application is to investigate the predictors (e.g., lifestyle, neuroimaging metabolic and genetic) of healthy ageing (e.g., cognitive, physical and mental health in older age).
Our objectives are to identify the contribution of predictors (lifestyle, medication-related, neuroimaging, metabolic, and genetic) of the following outcomes, that occur at greater frequency in older age:
1) Cognitive impairment (e.g., due to normal ageing or neurological disorders such as Alzheimer鈥檚 disease, stroke)
2) Poor physical health (e.g., osteoporosis, diabetes, falls and fractures)
3) Poor mental health (e.g., anxiety, depression, suicidal ideation) - 08-Jan-2023 - 09-Jan-2025
- Carswell, Hilary (Principal Investigator) Bushell, Trevor (Co-investigator) McMullen, Calum (Co-investigator) Seib, Philipp (Co-investigator)
- 04-Jan-2023 - 04-Jan-2028
- Bushell, Trevor (Principal Investigator) Sakata, Shuzo (Co-investigator)
- 01-Jan-2022 - 30-Jan-2025
- Bushell, Trevor (Principal Investigator) Sakata, Shuzo (Co-investigator)
- 01-Jan-2022 - 28-Jan-2023
Contact
Dr
Trevor
Bushell
Reader
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: trevor.bushell@strath.ac.uk
Tel: 548 2856